Cardiorespiratory fitness associated with reduced risk for dementia in US veterans

  • A study of 649,605 US veterans has identified an independent and graded association between cardiorespiratory fitness and reduced risk for Alzheimer's disease and related dementias (ADRD).
  • In all, 6.8% of the study population developed ADRD during a median follow-up of 8.3 years, giving an incidence rate of 7.7 per 1,000 person-years.
  • In a multivariable-adjusted analysis using the least-fit quintile as the reference group, people with increasing levels of cardiorespiratory fitness had decreasing risk for ADRD, with significant hazard ratios of 0.87, 0.80, 0.74, and 0.67 for individuals in the low-fit, moderate-fit, fit, and high-fit groups, respectively.