Brain functional activity constrained by high serum neurofilament levels predicts cognitive decline in Alzheimer disease

Prior research has linked serum neurofilament, measured in blood and cerebrospinal fluid, with neuronal damage; however, this is yet to be investigated with functional connectivity in people (n=106 autosomal dominant mutation carriers, n=76 non-carriers) living with Alzheimer disease.
These analyses indicated that neurofilament light chain facilitates worsened functional connectivity within and between the default mode network and executive control networks.
According to the authors, serum neurofilament levels indicates brain dysfunction in people with Alzheimer disease. Additionally, increased serum neurofilament levels is a potential biomarker of brain functional connectivity and cognitive decline in people with Alzheimer disease.