Brain functional activity constrained by high serum neurofilament levels predicts cognitive decline in Alzheimer disease

  • Prior research has linked serum neurofilament, measured in blood and cerebrospinal fluid, with neuronal damage; however, this is yet to be investigated with functional connectivity in people (n=106 autosomal dominant mutation carriers, n=76 non-carriers) living with Alzheimer disease.
  • These analyses indicated that neurofilament light chain facilitates worsened functional connectivity within and between the default mode network and executive control networks.
  • According to the authors, serum neurofilament levels indicates brain dysfunction in people with Alzheimer disease. Additionally, increased serum neurofilament levels is a potential biomarker of brain functional connectivity and cognitive decline in people with Alzheimer disease.