Brain biomarkers associated with migraine and cluster headache

  • Individuals with migraine can be distinguished from those with cluster headaches via differences in the left thalamic network on MRI. Cluster headache is associated with reduced functional interaction between left thalamus and specific cortical areas.
  • Differences between individuals with migraine and cluster headaches and healthy controls were noted in the bilateral hypothalamic and periaqueductal gray functional networks.
  • The authors concluded that the differences in biomarkers may be indicative of the differential clinical features exhibited by migraines and cluster headaches.