Blood-based biomarkers for Alzheimer disease in patients with hypoxic-ischemic injury after cardiac arrest

  • The prognostic potential of blood tau protein measurements (p-tau, Aβ42, Aβ40) to predict neurological outcomes following resuscitation from cardiac arrest is not well known.
  • A comparison between blood p-tau proteins and neural injury markers (neurofilament light [NfL] and total tau [t-tau]) was performed to understand changes of these biomarkers at 24, 48, and 72 hours after cardiac arrest. The increased secretion of blood p-tau after 24 hours was associated with poor neurologic outcome, whilst a decrease of p-tau after 24 hours was weakly associated with neurological outcome. Blood Aβ42 and Aβ40 biomarkers were weakly associated with neurological outcome.
  • According to the authors, blood tau biomarkers show changes after cardiac arrest. These changes are important for the prediction of neurologic outcome in patients with hypoxic brain injury after cardiac arrest.