Takeaway
Abnormal fatigue is a significant symptom for patients with Charcot-Marie-Tooth disease (CMT). It has multiple associations with disease severity, mood disorders, and obesity.
Why this matters
Perceived fatigue has been reported by a significant proportion of patients with CMT. This is commonly assessed with Modified Fatigue Impact Scale (MFIS) in other neuromuscular conditions, but CMT-specific data is limited.
Multidimensional management of fatigue should become an important aspect of CMT treatment.