APOE4 genotype and its differential effect on brain structural changes in Alzheimer’s disease


  • In early-onset Alzheimer’s disease (EOAD) and late-onset Alzheimer’s disease (LOAD), APOE genotype differentially affect Papez circuit structures as well as cognitive performance.

Why this matters?

  • The structural, cognitive and neuropsychiatric differences between EOAD (age at symptom onset <65 years) and LOAD (age at symptom onset ≥65 years) have been recognized. However, previous studies often lacked information on biomarker confirmation and/or APOE genotype.

  • Future research on AD and clinical trial designs should take APOE genotype as well as the age of symptom onset into consideration.