Antiseizure medication responses in PRRT2-associated infantile epilepsy


  • In patients with PRRT2-associated infantile epilepsy, sodium channel blockers, such as oxcarbazepine and carbamazepine, can reduce seizure frequency but levetiracetam cannot.

Why this matters

  • Pathogenic variants in PRRT2 have been identified as the main cause of self-limiting sporadic and familial infantile epilepsy, but data on treatment response to different antiseizure medications (ASMs) is lacking in these patients, which extends the time to optimal treatment.

  • Assessing the treatment responses to currently available ASMs can guide treatment choices for patients with PRRT2-associated infantile epilepsy to achieve improved outcomes.