Takeaway
In children and young adults with intellectual disability (ID), the NIH Toolbox Cognition Battery (NIHTB-CB) is able to detect growth over a 2-year period in various cognitive domains.
Why this matters
For individuals with ID such as fragile X syndrome (FXS), Down syndrome (DS), and other intellectual disability (OID), being able to accurately assess cognition is of great importance in a clinical trial setting. Although rigorous, full scale IQ tests, e.g. the Stanford Binet-5 (SB5) are often not suitable for determining treatment outcomes.
A tool to assess treatment outcomes and potentially track cognitive growth will build a deeper understanding of the natural history of ID and facilitate drug development.