25 years of community data examining the role of persistent physical activity on brain damage


  • Greater levels of leisure-time physical activity in mid-life may protect against cerebrovascular complications that can occur later in life.

Why this matters

  • Although physical activity has been associated with less cognitive decline and dementia, pathways that link physical activity to brain pathology outcomes have not been well studied in the community.

  • Clinical trials have mixed conclusions around the benefits of physical activity, which may be attributed to short follow-up periods and enrolling older patients with mild cognitive impairment. This is not reflective of the natural progression of life-long physical activity.